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2008•The Journal of Clinical PsychiatryRequires access

Adjunctive therapeutic effect of olanzapine on refractory depression

Wang Hua-yu

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Abstract

Objective:To explore the effect of venlafaxine combined with olanzapine in the treatment of refractory depression. Method:92 patients with treatment-refractory depression were randomly assigned into two groups,olanzapine combined with venlafaxine(combination group) and venlafaxine alone(single group) for 6 weeks.The clinical efficacy were evaluated by the hamilton depressive scale(HAMD) and the hamilton anxiety scale(HAMA).Adverse effects were assessed by the treatment emergent symptom scale(TESS). Results:As compared with the baseline scores,the HAMD scores as well as HAMA,the two groups decreased significantly after 6 weeks′treatment(P0.01),especially for combined group(P0.01orP0.05). Conclusion: The combination of olanzapine with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.

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Objective:To explore the effect of venlafaxine combined with olanzapine in the treatment of refractory depression. Method:92 patients with treatment-refractory depression were randomly assigned into two groups,olanzapine combined with venlafaxine(combination group) and venlafaxine alone(single group) for 6 weeks.The clinical efficacy were evaluated by the hamilton depressive scale(HAMD) and the hamilton anxiety scale(HAMA).Adverse effects were assessed by the treatment emergent symptom scale(TESS). Results:As compared with the baseline scores,the HAMD scores as well as HAMA,the two groups decreased significantly after 6 weeks′treatment(P0.01),especially for combined group(P0.01orP0.05). Conclusion: The combination of olanzapine with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.

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Available abstract

Objective:To explore the effect of venlafaxine combined with olanzapine in the treatment of refractory depression. Method:92 patients with treatment-refractory depression were randomly assigned into two groups,olanzapine combined with venlafaxine(combination group) and venlafaxine alone(single group) for 6 weeks.The clinical efficacy were evaluated by the hamilton depressive scale(HAMD) and the hamilton anxiety scale(HAMA).Adverse effects were assessed by the treatment emergent symptom scale(TESS). Results:As compared with the baseline scores,the HAMD scores as well as HAMA,the two groups decreased significantly after 6 weeks′treatment(P0.01),especially for combined group(P0.01orP0.05). Conclusion: The combination of olanzapine with venlafaxine is better than venlafaxine alone in the treatment of refractory depression.

Key concepts: Hamd, Olanzapine, Venlafaxine, Refractory (planetary science), Hamilton depression scale, Depression (economics), Internal medicine, Medicine

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