Analysis of ACE gene deletion polymorphism in patients with cerebrovascular diseases

Objective: To discuss the relationship between the ACE gene deletion polymorphism and cerebrovascular diseases. Methods: We detect the frequency of the deletion allele D and the polymorphism DD by using PCR techniques in 98 patients with cerebrovascular diseases compared with 52 normal age and sex method controls. Results: The allele frequency was 0.61 ∶ 0.49 in patients with cerebrovascular diseases and 0.43:0.57 in controls(P 0.05). The DD genotype was more common in patients with cerebrovascular diseases compared with controls(43/98 vs 10/52, P 0.05). The incidences of polymorphism DD and the frequency of the deletion allele D were higher in cerebral stroke with history of high blood pressure(P 0.05). While the incidence of the polymorphism DD and the frequency of the deletion allele D had no differences in cerebral stroke with or without family history of cerebral stroke(P 0.05). Conclusion :Our study shows the deletion polymorphism in the ACE gene may be a risk factor for both lacunar stroke and cerebral embolism. The deletion polymorphism in the ACE gene is associated with high blood pressure.