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Relationship between polymorphism of angiotensin converting enzyme gene and risk for stroke in elderly

Zhu Wu-sheng

Open publisher page 3 citations

Abstract

Objective To invastigate the relationship between angiotensin converting enzyme(ACE) gene polymorphism and risk for stroke in elderly.Methods Frequencies of ACE gene type and allele were sequenced in 186 stroke patients and 75 normal controls by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) technique.The stroke patients included 126 patients with cerebral infarction and 60 patients with cerebral hemorrhage.The PCR determined the sequence located in the 16th intron with 287 bp.Results Frequency of D allele was 41.9% in stroke patients and 31.3% in the controls(P0.05) and frequency of DD genotype was 21.5% in stroke patients and 9.3% in controls.The frequencies of DD genotype and D allele in cerebral hemorrhage and cerebral infarction groups were significantly higher than those in control group(P0.05).Conclusions The DD gene type of ACE and D allele may be the risk factor for stroke in elderly.

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Objective To invastigate the relationship between angiotensin converting enzyme(ACE) gene polymorphism and risk for stroke in elderly.Methods Frequencies of ACE gene type and allele were sequenced in 186 stroke patients and 75 normal controls by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) technique.The stroke patients included 126 patients with cerebral infarction and 60 patients with cerebral hemorrhage.The PCR determined the sequence located in the 16th intron with 287 bp.Results Frequency of D allele was 41.9% in stroke patients and 31.3% in the controls(P0.05) and frequency of DD genotype was 21.5% in stroke patients and 9.3% in controls.The frequencies of DD genotype and D allele in cerebral hemorrhage and cerebral infarction groups were significantly higher than those in control group(P0.05).Conclusions The DD gene type of ACE and D allele may be the risk factor for stroke in elderly.

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Available abstract

Objective To invastigate the relationship between angiotensin converting enzyme(ACE) gene polymorphism and risk for stroke in elderly.Methods Frequencies of ACE gene type and allele were sequenced in 186 stroke patients and 75 normal controls by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) technique.The stroke patients included 126 patients with cerebral infarction and 60 patients with cerebral hemorrhage.The PCR determined the sequence located in the 16th intron with 287 bp.Results Frequency of D allele was 41.9% in stroke patients and 31.3% in the controls(P0.05) and frequency of DD genotype was 21.5% in stroke patients and 9.3% in controls.The frequencies of DD genotype and D allele in cerebral hemorrhage and cerebral infarction groups were significantly higher than those in control group(P0.05).Conclusions The DD gene type of ACE and D allele may be the risk factor for stroke in elderly.

Key concepts: Genotype, Medicine, Allele, Angiotensin-converting enzyme, Internal medicine, Stroke (engine), Cerebral infarction, Allele frequency

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