Effect of different dose of rosuvastatin on C-Reactive protein and blood-fat in patients with coronary artery disease accompanied by hypercholesteremia

Objective To study the impact of different dose of rosuvastatin on the high-sensitivity C-reactive protein(hs-CRP) and blood-fat of patients with coronary artery disease(CAD) accompanied by hypercholesteremia(HC).Methods Sixty-three patients with coronary artery disease accompanied by hypercholesteremia from July 2010 to July2012 were divided into observation group and control group by drug dosage. The observation group was treated with rosuvastatin 40 mg/d, and the control group was treated with rosuvastatin 10 mg/d. The patients in two groups were measured hs-CRP, lipid components and general biochemical parameters before treatment and a month later. Results In each group, there were no significant differences in fasting plasma glucose(FPG), HDL-C and TG before and after treatment(P0.05). After rosuvastatin treatment for one month, TC, LDL-C, HS-CRP in two groups were all significantly lower than those before treatment(P0.05). The effect of reduction in the observation group was more significant than that in the control group(P0.05). Conclusion The rosuvastatin can effectively reduce the level of hs-CRP and blood-fat of patients with CAD accompanied by HC. High-dose of rosuvastatin was more effective than conventional-dose.