The clinical study of rosuvastatin therapy of different doses on hs-CRP leves in patients in early phase with acute coronary syndrome

OBJECTIVE To investigate the effect of different doses of rosuvastatin on serum high sensitivity C-reactive protein and blood lipid levels in early phase of acute coronary syndrome.METHODS A total of 100 patients with ACS were randomly assigned into the large dosage of rosuvastatin(40mg·d-1)group(n=50)and the routine dosage of rosuvastatin(20mg·d-1)(n=50).Serum levels of blood lipid,hs-CRP were measured with biochemistry assay 24 hour after admission and 3 days and 7 days after therapy.The difference in blood lipid,hs-CRP was compared between the two groups.RESULTS Among the two groups,the levels of TC and LDL-C decreased significandy after treatment(P0.05),in the large dosage of rosuvastatin group,the levels of hs-CRP decreased significandy comparing with the routine dosage of rosuvastatin group(P0.01),but no visible statistic differences were found in TC,and LDL-C among the two groups.CONCLUSION Effect of early rosuvastatin therapy of the large dosage on serum hs-CRP leves is better than the routine dosage in patients with acute coronary syndrome.The anti-inflammatory effect of rosuvastatin is not related to lipid lowering.