Expression and clinical significance of Bcl-2、NF-KB in adenoid cystic carcinoma of the parotid gland

Objective To explore the expression and Clinical Significance of Bcl-2,NF-KB in in Adenoid Cystic Carcinoma of the Parotid Gland.Methods Detected the expression of Bcl-2,NF-KB gene protein in 49 cases of adenoid cystic carcinoma of parotid gland was block embedded tissue in Immunohistochemistry SP method,20 cases of normal parotid tissue as control.Using χ2 test,the statistically significant difference is defined as P 0.05.Results The total expression rate of Bcl-2 and NF-KB in adenoid cystic carcinoma group are significantly higher than the normal parotid group(P0.05),the expression of different pathological typing of Bcl-2 and NF-KB are no differences(P 0.05),the expression of clinical TNM stage of Bcl-2 and NF-KB are differences(P0.05).There is positive correlation between Bcl-2 and NF-KB(P0.05 kappa=0.387).Conclusion NF-KB plays a important role by up-regulating the expression of Bcl-2 in the occurrence and development process of adenoid cystic carcinoma of parotid gland.