Expression of ebp1 in adenoid cystic carcinoma and its clinic-pathologic significances

Objective To investigate the expression of ebp1 in adenoid cystic carcinoma and its clinic-pathologic significance. Methods Immunohistochemistry(PV6000 method) was used to detect ebp1 expression in paraffin-embedded adenoid cystic carcinoma tissues of 35 cases and matched para-cancerous normal tissues.In this study all cases were successfully followed up. Results The positive expression rate of ebp1 in adenoid cystic carcinoma tissues was 74.3%.ebp1 expression was significantly correlated to pathological pattern and clinical stage(P0.05),but not correlated to gender and age(P0.05).In addition,the 5-year survival rate of the patients with ebp1 expression was higher than those with negative expression(P0.05). Conclusions ebp1 plays an important role in the generation and evolution of adenoid cystic carcinoma,and can be used as an useful indicator for clinical assessment of tumor biological behavior and prognosis in patients with adenoid cystic carcinoma.