Pharmacokinetics and relative bioavailability of compound aminophylline bromhexine and chlorphenamine tablets in healthy volunteers

Objective To study the pharmacokinetics and relative bioavailability of theophylline in compound aminophylline bromhexine and chlorphenamine tablets.Methods The concentration of theophylline in human plasma was determined by HPLC-UV.The relative bioavailability and pharmacokinetic parameters of theophylline were calculated by using the non-compartment dynamics theory.Results The main pharmacokinetic parameters of theophylline (test formulation and reference formulation) were as follow:tmax were (1.3 ± 1.7) and (1.5 ± 1.9) h,ρmax were (3 004 ± 846) and (2 947 ± 762) μg·L-1,t1/2 were (9.3 ± 3.4) and (8.5 ± 2.6) h,AUC0→t were (29 715 ± 12 295) and (31 547 ± 12 465) μg·h·L-1,AUC0→∞ were (33 688 ± 12 705) and (32 436 ± 13 093) μg·h·L-1,respectively.The bioavailability of theophylline was (96.1± 21.7) %.Conclusions No significant difference was found between the test and reference formulation in the pharmacokinetic parameters of theophylline.