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Therapeutic effects of shark hepatic regenerative factor on chronic liver injury in rats

WU Wu-tong

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Abstract

AIM:The purpose of this study was to evaluate the therapeutic effects of shark hepatic regenerative factor(sHRF)on chronic liver injury in rats.METHODS:Chronic hepatic injury model in rats was induced by Carbon tetrachloride(CCl4).The activities of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),the content of albumin and total protein in the serum and Hydroxyproline in the liver were measured.RESULTS:Statistics indicated that chronic liver-injured rats with administration for 8 weeks,sHRF could suppress the elevation of ALT,AST in serum and Hydroxyproline in liver of liver injury rats induced by CCl4.There were no significant differences at the dosage of 0.8,1.6 mg/kg.Moreover,sHRF could increase albumin level and the ratio of albumin and globulin in serum.Hepatic histological findings indicated that sHRF could alleviate liver fibrosis and liver steatosis.CONCLUSION:sHRF had therapeutic effect on chronic liver injury in rats induced by Carbon tetrachloride.

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AIM:The purpose of this study was to evaluate the therapeutic effects of shark hepatic regenerative factor(sHRF)on chronic liver injury in rats.METHODS:Chronic hepatic injury model in rats was induced by Carbon tetrachloride(CCl4).The activities of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),the content of albumin and total protein in the serum and Hydroxyproline in the liver were measured.RESULTS:Statistics indicated that chronic liver-injured rats with administration for 8 weeks,sHRF could suppress the elevation of ALT,AST in serum and Hydroxyproline in liver of liver injury rats induced by CCl4.There were no significant differences at the dosage of 0.8,1.6 mg/kg.Moreover,sHRF could increase albumin level and the ratio of albumin and globulin in serum.Hepatic histological findings indicated that sHRF could alleviate liver fibrosis and liver steatosis.CONCLUSION:sHRF had therapeutic effect on chronic liver injury in rats induced by Carbon tetrachloride.

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Available abstract

AIM:The purpose of this study was to evaluate the therapeutic effects of shark hepatic regenerative factor(sHRF)on chronic liver injury in rats.METHODS:Chronic hepatic injury model in rats was induced by Carbon tetrachloride(CCl4).The activities of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),the content of albumin and total protein in the serum and Hydroxyproline in the liver were measured.RESULTS:Statistics indicated that chronic liver-injured rats with administration for 8 weeks,sHRF could suppress the elevation of ALT,AST in serum and Hydroxyproline in liver of liver injury rats induced by CCl4.There were no significant differences at the dosage of 0.8,1.6 mg/kg.Moreover,sHRF could increase albumin level and the ratio of albumin and globulin in serum.Hepatic histological findings indicated that sHRF could alleviate liver fibrosis and liver steatosis.CONCLUSION:sHRF had therapeutic effect on chronic liver injury in rats induced by Carbon tetrachloride.

Key concepts: Carbon tetrachloride, Hydroxyproline, Albumin, CCL4, Liver injury, Internal medicine, Steatosis, Medicine

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