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Effects of Shark Hepatic Regenerative Factor on Acute Chemical Liver Injury in Mice

Dou Chang

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Abstract

To observe the effect of Shark Hepatic Regenerative Factor( sHRF)on acute chemical liver injury in mice. The lever of ALT and AST in the serum were measured and histopathological slices of livers were examined, after the acute liver injury models had been created by chemical drugs. sHRF can significantly inhibit the abnormal elevation of ALT and AST in the serum caused by CCl 4 ,TAA and D GalN, and obviously relive their histopathological liver injury. It is concluded that sHRF have active effect on acute chemical liver injury in mice.

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What this paper is about

To observe the effect of Shark Hepatic Regenerative Factor( sHRF)on acute chemical liver injury in mice. The lever of ALT and AST in the serum were measured and histopathological slices of livers were examined, after the acute liver injury models had been created by chemical drugs. sHRF can significantly inhibit the abnormal elevation of ALT and AST in the serum caused by CCl 4 ,TAA and D GalN, and obviously relive their histopathological liver injury. It is concluded that sHRF have active effect on acute chemical liver injury in mice.

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Available abstract

To observe the effect of Shark Hepatic Regenerative Factor( sHRF)on acute chemical liver injury in mice. The lever of ALT and AST in the serum were measured and histopathological slices of livers were examined, after the acute liver injury models had been created by chemical drugs. sHRF can significantly inhibit the abnormal elevation of ALT and AST in the serum caused by CCl 4 ,TAA and D GalN, and obviously relive their histopathological liver injury. It is concluded that sHRF have active effect on acute chemical liver injury in mice.

Key concepts: Liver injury, Liver tissue, Medicine, Histopathological examination, Acute injury, Pathology, Internal medicine, Pharmacology

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