ScholarLens Back to search
2008•Pharmaceutical biotechnologyRequires access

Protective Effect of Shark Hepatic Regenerative Factor on Alcoholic Liver Injury in Rats

WU Wu-tong

Open publisher page 0 citations

Abstract

To study the protective effect of shark Hepatic Regenerative Factor(sHRF) on alcoholic liver injury in rats,alcoholic liver disease of animal model was established by ig.alcohol. The activities of Serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST,the contents of albumin,total protein,malondialdehyde(MDA),triglycerides(TG) and Superoxide Dismutase(SOD) in liver tissue were measured after 5 weeks.The results showed that sHRF could not only create a prominent prevention to the abnomal increase in ALT and AST in rats' serum induced by alcohol,but also restrain the increase of triglyceride in the hepatic tissue of rats.In addition,sHRF could lead albumin content to increase,but the content of total protein was without obvious change.Besides,sHRF administrating group could apparently enhance the activity of SOD,reduce the content of MDA,improve the rats' eliminating ability of oxygen free radicals in the body,as well as reduce the injury of lipid peroxide to tissues and organs.Tissue slice displayed that the hepatic pathological changes of the administrating group are less severe than those of the model group.It was concluded that sHRF had significant protective effect on alcoholic liver injury in rats.

About this research paper

What this paper is about

To study the protective effect of shark Hepatic Regenerative Factor(sHRF) on alcoholic liver injury in rats,alcoholic liver disease of animal model was established by ig.alcohol. The activities of Serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST,the contents of albumin,total protein,malondialdehyde(MDA),triglycerides(TG) and Superoxide Dismutase(SOD) in liver tissue were measured after 5 weeks.The results showed that sHRF could not only create a prominent prevention to the abnomal increase in ALT and AST in rats' serum induced by alcohol,but also restrain the increase of triglyceride in the hepatic tissue of rats.In addition,sHRF could lead albumin content to increase,but the content of total protein was without obvious change.Besides,sHRF administrating group could apparently enhance the activity of SOD,reduce the content of MDA,improve the rats' eliminating ability of oxygen free radicals in the body,as well as reduce the injury of lipid peroxide to tissues and organs.Tissue slice displayed that the hepatic pathological changes of the administrating group are less severe than those of the model group.It was concluded that sHRF had significant protective effect on alcoholic liver injury in rats.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

To study the protective effect of shark Hepatic Regenerative Factor(sHRF) on alcoholic liver injury in rats,alcoholic liver disease of animal model was established by ig.alcohol. The activities of Serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST,the contents of albumin,total protein,malondialdehyde(MDA),triglycerides(TG) and Superoxide Dismutase(SOD) in liver tissue were measured after 5 weeks.The results showed that sHRF could not only create a prominent prevention to the abnomal increase in ALT and AST in rats' serum induced by alcohol,but also restrain the increase of triglyceride in the hepatic tissue of rats.In addition,sHRF could lead albumin content to increase,but the content of total protein was without obvious change.Besides,sHRF administrating group could apparently enhance the activity of SOD,reduce the content of MDA,improve the rats' eliminating ability of oxygen free radicals in the body,as well as reduce the injury of lipid peroxide to tissues and organs.Tissue slice displayed that the hepatic pathological changes of the administrating group are less severe than those of the model group.It was concluded that sHRF had significant protective effect on alcoholic liver injury in rats.

Key concepts: Malondialdehyde, Superoxide dismutase, Lipid peroxide, Albumin, Liver injury, Internal medicine, Alcoholic liver disease, Alcohol

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Protective Effect of Shark Hepatic Regenerative Factor on Alcoholic Liver Injury in Rats — Research Paper | ScholarLens