2007•Zhonghua zhongyiyao xuekanRequires access

Determination of Baicalin in Xiaoerganke Granules by HPLC

QU Lei-ming

Abstract

Objective:To develop a HPLC method for the determination of Baicalinin Xiaoerganke Granules.Methods:A DiamonsilTM C_18(250mm×4.6mm,5μm) was used,the mobile phase was methanol-water-H_3PO_4(49∶51∶0.2);the flow rate was:1.0mL/min;the wavelength for detection was 280nm.Results:The average recovery rate for Baicalinwas 98.6%,and RSD was 1.3%.The RSD of the reproducibility was 2.0%.Conclusion:The procedure is simple and reliable.The results are stable and reproducible.The method can be used for evaluation the quality of Xiaoerganke Granules.

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Key concepts: Baicalin, Chromatography, Reproducibility, Chemistry, High-performance liquid chromatography, Recovery rate, Volumetric flow rate, Analytical Chemistry (journal)