The serum adiponectin changes and its role in women with gestational diabetes mellitus

Objective To investigate the relation between the gestational diabetes mellitus and the changes of serum adiponectin. Methods 104 pregnant women were selected. According to the results of 75g OGTT, they were divided into 2 groups: gestational diabetes mellitus group (GDM) and normal glucose tolerance group( NGT).The serum adiponectin were measured by using RIA.Serum glucose,lipid and insulin were also measured on fasting samples.Results The level of adiponectin,ISI and HOMA-B were significantly decreased in GDM group compared with that of the NGT group. The levels of FBG, Lipid, HOMA-IR were significantly increased in GDM group compared with that of the NGT group. Correlation was found between the level of adiponectin with HOMA-IR,FBG,FIns,pre-BMI and ISI. Logistic analysis showed that GDM was significantly related with hypoadiponectin,pre-BMI, cholesterol and family history of diabetes mellitus.Conclusions The serum adiponectin level in the GDM group decreases significantly than the NGT group. Decreased adiponectin concentration in GDM may not simply reflect maternal adiposity and insulin resistant state, but may contribute to the impaired glucose metabolism during pregnancy. Hypoadiponectin is one of the main risk factors in predicting and screening of GDM.