Maternal serum adiponectin concentration and correlation with insulin resistance in gestational diabetes mellitus

Aim:To investigate serum concentration of adiponectin and its correlation with insulin resistance in pregnant women with gestational diabetes mellitus(GDM).Methods:ELISA was used to measure serum adiponectin levels of 30 women with GDM ,35 cases of NGT women and 15 cases of healthy normal control. Insulin resistance index(HOMA-IR) and HOMA-HBCI was calculated.Results:①Levels of adiponectin decreased significantly from control subjects、NGT subjiects to GDM patients. Levels of HOMA-IR increased significantly from control subjects、NGT subjiects to GDM patients.②Serum adiponectin was negatively correlated with HOMA-IR and other corresponding parameters. ③HBCI of GDM patients was lower significantly than that of NGT and NC subjects. ④The multivariate regression analysis revealed that HOMA-IR,FPG were the most influential factors that affects adiponectin.Conclusion: ①GDM patients involved more seriously insulin resistance. ②Adiponectin may contribute to relieve insulin resistance of GDM patients. ③The defect of function of B cell played the important role in the pathogenesis of GDM.