STUDY ON THE DISINFECTION PERFORMANCE OF A COMPOUND PHENOLS HAND AN-TISEPTIC GEL

Objective To study the disinfection performance of the compound hand antiseptic gel with PCMX as the main germicidal ingredients so as to provide a scientific basis for its practical application. Methods The physical and chemical analysis,carrier quantitative bactericidal test and animal test were used to carry out laboratory of this disinfection. Results After the compound hand antiseptic gel containing PCMX 0. 274% and ethanol 58. 3% being deposited at 37℃ for 90 days,the two kinds of effective component content decreased 5%. The killing logarithm values of Staphylococcus aureus、 Pseudomonas aeruginosa、Escherichia coli and Candida albicans on the carriers exposed to the compound hand-disinfectant gel disinfectant for 0. 5 min were more than 3. 0. The killing logarithm value of the natural bacteria in the hands exposed to the disinfectant for 1. 0 min was more than 1. 0. The LD 50 of the compound hand-disinfectant gel in mouse oral toxicity test was 5 000 mg / kg·bw. The disinfectant had no skin nonirritant and it did not cause micronucleus formation in mouse bone marrow polychromatophilic erythrocytes. Conclusion This compound hand-disinfection is stable and has a quick killing effect on the vegetative form of bacteria and fungi. It has no toxicity,no irritation on the skin and has no mutagenic action.