Laboratory observation on disinfection property and toxicity of compound hands-free disinfectant.

Objective:To explore disinfections function,toxicity,bactericidal effect and security of compound hands-free disinfectant.Methods: The physical and chemical analysis,quantitative bactericidal test carrier immersion and animal toxicity testing methods on physical and chemical properties and bactericidal effect of laboratory and field observations and the use of safety valuation.Results: With the average ethanol content of 56%,the average concentration of triclosan 0.24% of the free hand disinfectant against Escherichia coli,Staphylococcus aureus,Candida albicans,the role of time are respectively 0.5 min,and 1.5 min on the role of P.aeruginosa,all of the kill Logarithm 5.00.Hand disinfection field test,the subjects rubbed their fingers flexor surface of liquid fingertips to refer to root,rub the role of 1.0min,on the natural bacteria in the hands of 30 volunteers,the average killing rate is 96.55%.The number of residual bacteria after treatment the skin is 0 cfu/cm~5 cfu/cm.The disinfectant oral LD50 on rats,male and female are greater than 5000 mg/kg(body weight);The average number of rabbit skin irritation test stimulation index is 0.05;Acute eye irritation in rabbits is a non-irritating;Polychromatic erythrocytes of mouse bone marrow micronucleus induced no effect.Conclusion: The hands-free disinfectant compound have a very good role in the killing on multiplication of bacteria and fungi,are real non-toxic and non-irritating to the intact skin.