THE ACTION OF INFLAMMATION IN CORONARY HEART DISEASE

Objective: To investigate correlation between inflammatory reaction and coronary heart disease. Methods: This study included 114 patients with acute myocardial infarction(AML group), 39 patients with unstable angina pectoris (UAP group) and 28 patients with essential hypertension (EH group). IgG, IgA, CRP, IL-6, TNF-α were measured in peripheral blood serum samples. Results: (1) Both IgA and IgG level were in normal range in all groups. But IgG level was significantly higher in UAP group than AMI group (P0 01)。(2) The level of CRP, IL-6, TNF-α were higher in group AMI and UAP than other groups, especially in group UAP, compared with EH group P0 05. Conclusion: There was a significant positive correlation between inflammatory reaction and coronary heart disease especially in AMI and UAP. Increase of the level of CRP, IL-6 and TNF-α in all subjects indicates inflammatory reaction. Antibiotics, aspirin and tanting drugs may be available.