Chemokine CXCL16 expression in serum of patients with coronary artery disease

Objective To investigate the role of soluble CXC chemokine 16(CXCL16) in coronary atherosclerotic disease.Methods There were 69 patients with coronary artery disease(CHD) enrolled,including 16 patients with acute myocardial infarction(AMI),26 patients with unstable angina pectoris(UAP) and 27 patients with stable angina pectoris(SAP),and 19 normal controls.The expressions of CXCL16,tumor necrosis factor-alpha(TNF-α) in serum were compared using enzyme linked immunosorbent assay(ELISA),and the relationship between serumsoluble CXCL16 and Gensini score was also analyzed.Results The levels of CXCL16 in peripheral blood in UAP and AMI groups were significantly higher than those in SAP group and normal controls(P0.05);however,there was no significant difference in CXCL16 expression between UAP group and AMI group(P0.05),nor did between SAP group and normal controls.And no significant correlation was found between serumsoluble CXCL16 and TNF-α or Gensini score(r=0.154,0.195 respectively,both P0.05).The serum levels of TNF-α in SAP,UAP and AMI groups were significantly higher than those in normal controls(all P0.01),UAP group was significantly higher than SAP group(P0.01),and AMI group was significantly higher than UAP group(P0.05).Gensini score was significantly increased in UAP and AMI groups compared to SAP group,but no significant difference was found between UAP and AMI group.Conclusion CXCL16 may play an important role in the pathogenesis and development of acute coronary syndrome.