CRP, IL-6 and TNF-α in patients with coronary heart disease

Objective:To investigate the relation of inflammation markers to Coronary heart disease (CHD) and the clinical significance by observing the changes of CRP, IL-6, TNF-α during agina pectoris and acute myocardial infarction.Method:All persons were divided into control group , stable agina pectoris group(SAP) , unstable agina pectoris group(UAP) and acute myocardium infarction group(AMI) , The concentration of CRP was determined by scatter turbidimetry , and the concentration of IL-6 and TNF-α by ELISA.Result:①In SAP, UAP and AMI groups, the levels of CRP, IL-6 and TNF-α were significantly(P 0.01) increased compared with that in Control group; ②Compared with SAP group, the levels of CRP and TNF-α in UAP group increased (P 0.01); ③In AMI group, the levels of CRP, IL-6 and TNF-α were higher (P 0.01), (P 0.05); ④The levels tham that in SAP and UAP group of CRP, IL-6 and TNF-α significantly inorease during 72 h in group AMI.Conclusion:The levels of inflammation factors in serum are related to the seropisemss of CHD.