2010•Laboratory Medicine and ClinicRequires access

Contrast study of treating schizophrenia by quetiapine and clozapine

Nie Xiao-xu

Abstract

Objective To study the efficacy and side effects of quetiapine and clozapine in the treatment of schizophrenia.Methods 80 patients were randomly divided into quetiapine group and clozapine group for treatment of 6 weeks.The efficacy and side effects were measured with the positive and negative symptoms scale(PANSS),while the adverse events were determined by the treatment emergent symptoms scale(TESS).Results The efficacy rate was 85% in quetiapine group and 80% in clozapine group.At the end of first week,the total scores of PANSS in the quetiapine group was higher than that before treatment with statistical significance(P0.05).The patients in quetiapine group reported few side effects.Conclusion Quetiapine possessing efficacy is similar to that of clozapine,but it takes effects more quickly with few side effects.

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Key concepts: Quetiapine, Clozapine, Schizophrenia (object-oriented programming), Medicine, Negative symptom, Internal medicine, Adverse effect, Side effect (computer science)