Comparison study in the treatment of schizophrenia between quetiapine and clozapine

Objective:To compare the clinical efficacy and safety between quetiapine and clozapine in the treatment of schizophrenia. Methods: 120 patients with schizophrenia were randomly divided into two groups, quetiapine group and clozapine group for 12 weeks. Positive and negative symptom scale (PANSS), treatment emergent symptom scale (TESS), and short form 36 health survey questionnaire ( SF - 36 ) were used to evaluate the efficacy or safety. Results: The total scores of PANSS obviously decreased in both groups and there was no significant difference between the two groups after treatment ( P 0.05 ). The incidence rate of side effects in quetiapine group was significant lower than that in clozapine group (P 0.05 ). Conclusions: quetiapine is a safe and effective antipsy - chotic drug, with similar efficacy as clozapine and fewer side effects in the treatment of schizophrenia.