The effect of irbesartan and amiodarone in patients with paroxysmal atrial fibrillation

Objective To evaluate effects of irbesartan and low dose amiodarone in patinets with paroxysmal atrial fibrillation who had normal heart function,and long-term therapeutic effect of maintain sinus rhythm.Methods A total of 142 patinets with paroxysmal atrial fibrillation were divided into two groups randomly:amiodarone group(n = 72),irbesartan and amiodarone group(n = 72),term of follow-up was 18 months.First class end point was atrial fibrillation recrudescence.The post-treatment rate of maintain sinus rhythm,and inner diameter of left au- ricle at pretherapy and post-treatment for 6,12,18 months with amiodarone group and irbesartan and amiodarone group were compared.Results After treatment for 12 months,inner diameter of left auricle in amiodarone group ex- ceeded irbesartan and amiodarone group(P0.05).At end point,sustain rate of sinus rhythm in amiodarone group was 58.04 %,and that of combination medication group was 84.06 %,there was significant difference between two groups(P0.05).Conclusion Irbesartan and amiodarone surpassed amiodarone in sustaining rate of sinus rhythm and inhibited left auricle enlargement.