Correlation of Expressions of C-erbB-2,ER and PR to Clinicopathologic Factors in Primary Breast Cancer

Objective To investigate the expressions of C-erbB-2,estrogen receptor(ER) and progesterone receptor(PR) in breast cancer tissues and to explore their relationship with patients' age,tumor size,lymph node metastasis,histopathological type and the stage of cancer.Methods The expressions of C-erbB-2,ER and PR in 83 cases of breast cancer tissues were detected by immunohistochemistry and the clinical significance was statistically analyzed.Results The positive expression rate of C-erbB-2,ER and PR in 83 cases of breast cancer tissues were 78.3%,56.6%and 55.4%,respectively.The expressions of C-erbB-2,ER and PR were not correlated to patients' age,tumor size,histopathological type and the stage of cancer(P0.05).While the expression of C-erbB-2 rather than ER and PR was correlated to lymph node metastasis(P0.05) and the correlation was positive(r=0.387,P0.05).Conclusion The positive expression of C-erbB-2 is one of lymph node metastasis factors for breast cancer patients.Combined detection of ER and PR expression may be helpful to clinical treatment and predict prognosis for breast cancer patients.