Expressions of c-erbB-2,ER and PR in Breast Cancer and Their Clinical Significances

Objective To investigate the expressions of c-erbB2,estrongen receptor(ER),progesterone(PR) in breast cancer tissue and their clinical significance.Methods The expression of c-erbB-2,ER,PR in 54 cases of breast cancer tissue were assessed by immunohistochemistry,and the correlation between that and its clinical significance was statistically analyzed.Results Positive expression rate of c-erbB-2,ER,PR in 54 cases of breast cancer tissue was 48.2%(26/54),53.7%(29/54),72.2%(39/54),the expression of ER,PR didn't cor relate to age,lymph node status and the structural type of breast cancers(P0.05).Expression of c-erbB-2 correlated with lymph node status(P0.05),didn't correlate to age,lymph node status and the structural type of breast cancer(P0.05).The consistent rate of c-erbB-2,ER,PR in 54 casees of breast cancer tissue was 46.3%(25/54),different rate was 27.8%(15/54),the expression of ER、PR was not associated with c-erbB-2(P0.05).Conclusion c-erbB-2 positive expression is a poor prognosis factor for breast cancer patients.Combined detection of ER and PR may be helpful to clinical treatment and prognostic judgement on breast cancer patients.