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2001•Journal of Jiangsu Clinical MedicineRequires access

EXPRESSION OF ER、PR、 C-erbB-2 IN BREAST CANCER AND THEIR CLINICAL SIGNIFICANCE

Pan Liang-xi

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Abstract

Objective:To investigate the expression and clinical significance of ER 、PR and C-erbB-2 in breast cancer.Methods:158 cases with primary breast cancer were examined for ER、PR and C-erbB-2 by immunohistochemical S-P methods.Results:The expressions of ER、PR and C-erbB-2 were 68.4%、62.0%、54.4% respectively.ER expression was significantly correlated with PR expression(P0.01).C-erbB-2 expression was in correlation with axillary lymph node metastasis(P0.05).There was a negative correlation between C-erbB-2 and ER、PR(P0.01).Patients with ER positive and PR positive or C-erbB-2 negative had higher 4-year DFS and 4-year OS than those with ER negative and PR negative or C-erbB-2 positive.Conclusion:The detection of ER and PR may be useful for guiding clinical treatment.The expression of C-erbB-2 is a useful mark for predicting the prognosis of patients with breast cancer.

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Objective:To investigate the expression and clinical significance of ER 、PR and C-erbB-2 in breast cancer.Methods:158 cases with primary breast cancer were examined for ER、PR and C-erbB-2 by immunohistochemical S-P methods.Results:The expressions of ER、PR and C-erbB-2 were 68.4%、62.0%、54.4% respectively.ER expression was significantly correlated with PR expression(P0.01).C-erbB-2 expression was in correlation with axillary lymph node metastasis(P0.05).There was a negative correlation between C-erbB-2 and ER、PR(P0.01).Patients with ER positive and PR positive or C-erbB-2 negative had higher 4-year DFS and 4-year OS than those with ER negative and PR negative or C-erbB-2 positive.Conclusion:The detection of ER and PR may be useful for guiding clinical treatment.The expression of C-erbB-2 is a useful mark for predicting the prognosis of patients with breast cancer.

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Available abstract

Objective:To investigate the expression and clinical significance of ER 、PR and C-erbB-2 in breast cancer.Methods:158 cases with primary breast cancer were examined for ER、PR and C-erbB-2 by immunohistochemical S-P methods.Results:The expressions of ER、PR and C-erbB-2 were 68.4%、62.0%、54.4% respectively.ER expression was significantly correlated with PR expression(P0.01).C-erbB-2 expression was in correlation with axillary lymph node metastasis(P0.05).There was a negative correlation between C-erbB-2 and ER、PR(P0.01).Patients with ER positive and PR positive or C-erbB-2 negative had higher 4-year DFS and 4-year OS than those with ER negative and PR negative or C-erbB-2 positive.Conclusion:The detection of ER and PR may be useful for guiding clinical treatment.The expression of C-erbB-2 is a useful mark for predicting the prognosis of patients with breast cancer.

Key concepts: Medicine, Breast cancer, Immunohistochemistry, Internal medicine, Clinical significance, Oncology, Lymph node metastasis, Metastasis

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EXPRESSION OF ER、PR、 C-erbB-2 IN BREAST CANCER AND THEIR CLINICAL SIGNIFICANCE — Research Paper | ScholarLens