Cervical Liquid-Based Cytology Combined Human Papillomavirus Testing in Cervical Lesion

Objective To study the significance of combination of cervical liquid-based cytology and human papillomavirus detection in cervical lesion screening.Methods From March 2010 to December 2011,3,028 patients were detected with nipple shaped tumor virus(HPV) and cervical liquid base cytology(TCT),TCT was used by 2001 International Cancer Association TBS diagnosis system report way,to the patients with positive results of TCT check for ASCUS and the above lesions and(or) HPV detection,cervical organization biopsy under electronic vaginal mirror were performed.Results The sensitivity of TCT check was 56.72%,with the specificity of 28.19%;the sensitivity of HPV check was 86.03%,with specific for 46.38%;among 408 cases of CIN and cervical cancer pathology,28 cases were single TCT positive(6.86%);with TCT and HPV positive 203 cases(49.75%),there was significant difference in diagnosis of cervical squamous intraepithelial neoplasm(CIN) and cervical cancer(χ2=184.926,P=0.000) between single TCT check and combination of TCT and HPV examination.Conclusion TCT combined with HPV check can improve the detection rate of cervical cancer and precancerous lesions,improve the sensitivity and specificity of screening,effectively reduce the TCT in detection of false-negative rates,and avoid excessive colposcopy and biopsy in low-risk populations and over-treatment.