Significance of HPV、TCT and Colposcopy for Cervical Cancer Screening

Objective To investigate the clinical efficacy of HPV,TCT and colposcopy in screening of early cervical lesions clinical. Methods 1 260 cases of cervical cancer were detected by liquid-based cytology( liquid-based thinlayer cytology test,TCT),high-risk human papilloma virus( human papilloma virus,HPV) DNA testing and colposcopy positioned under cervical biopsy,and cervical biopsy results confirmed standard histopathological evaluation HPV,TCT and joint detection for early diagnosis of cervical cancer effect. Results Liquid-based cytology test( TCT) showed that there was no intraepithelial lesion or malignant cells,normal and benign inflammation 1 037 cases,accounting for 82. 30%; the remaining 223 cases occurred without a clear sense of atypical squamous cells( ASCUS),low-grade squamous intraepithelial lesions( LSIL),high-grade squamous intraepithelial lesions( HSIL),squamous cell carcinoma( SCC),TCT showed positive detection rate of 17. 70%. HPV-DNA testing found that 659 patients had 1 or more of the HPV infection,HPV-DNA positive rate was 52. 30%; For TCT combined with the highest and HPV-DNA genotyping sensitivity,all indicators showed 262 patients had a positive indictor,compared with a single TCT and HPV-DNA genotyping,the detection rate was significantly higher,χ2values was 71. 610,40. 971,P values was 0. 000,0. 000 ratio. Conclusion The clinical use of HPV-DNA,liquid-based cytology and colposcopy for early screening of cervical cancer,is an efficient and feasible solution,and the combined detection of cervical precancerous lesions can improve the detection rate and reduce the rate of misdiagnosis. Early screening for cervical cancer is important.