Clinical studies of high-risk HPV examination and TCT in the early diagnosis of cervical cancer and precancerous lesions

Objective To investigate the clinical value of the high-risk types of human papillomavirus(HPV) examination and thinprep cytologic test(TCT) in the early diagnosis of cervical cancer and precancerous lesions.Methods High-risk HPV and TCT examination results in 1248 women screened for cervical cancer were retrospectively analyzed.The clinical diagnostic value of high-risk HPV and TCT examination and the combination of the two methods was compared.Results High-risk HPV infection rate and TCT-positive rate in cervical intraepithelial neoplasia(CIN) Ⅰgroup,CIN Ⅱgroup,CIN Ⅲ group,and cervical cancer group were significantly higher than those in normal and inflammatory group(all P 0.05).The sensitivity,correct diagnosis index,negative predictive value and positive predictive value of the combined detection improved to varying degrees and they were 92.2%,0.71,99.6% and 40.2%,respectively.Conclusion The combined detection of high-risk HPV and TCT has important clinical significance for the early diagnosis of cervical cancer.