2008•Chinese Journal of Drug Application and MonitoringRequires access

Study on protective effect of APS on chronic liver injury in wistar rats

Yuanyan Hu

Abstract

Objective:To investigate the protective effect of APS on chronic liver injury in rats.Methods:The chronic liver injury model of rats were induced by carbon tetrachloride(CCl4).To measure the changes of activity of serum alanine aminotrans-ferase(ALT),aspartate aminotransferase(AST),albumin(ALB) and the hydroxyproline(HyP) in hepatic tissue,and observe the patho-logic changes of hepatic tissue.Results:APS could decrease the concentration of serum ALT,AST,HA and HyP,increase the con-centration of serum TP and ALB,and improve the pathologic change of hepatic tissue in rats significantly.Conclusion:APS has protective functions on rats with chronic liver injury significantly.

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Key concepts: Medicine, Hydroxyproline, Carbon tetrachloride, CCL4, Chronic hepatic, Albumin, Liver injury, Liver tissue