Study on protective effects of reorganization human Kunitz protease inhibitor domain of amyloid protein precursor variant on chronic liver in jury in Wistar rats

Objective To investigate the protective effect of the reorganization human Kunitz protease inhibitor domain of amyloid protein precursor variant (rhKD/APPvar)agaist chronic hepatic injury in rats.Methods The chroni hepatic injury model of rats were induced by carbon tetrachloride(CCl4).Measuring the changes of activity of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB),albumin/globulin(A/G),sialic acid(SA),choline esterase(CHE),alkaline phosphatase(ALP) and the hydroxyproline(Hyd) in the liver tissue,Observing the pathologic change of liver tissue.Results The rhKD/APPvar could decrease the concentration of serum ALT,AST,ALP and Hyol.The rhKD/APPvar could increase the concentration of serum ALB,A/G,SA,CHE ignificantly.The rhKD/APPvar could improve the pathologic change of liver tissue of chroni hepatic injury significantly.Conclusion The rhKD/APPvar has protective functions on rats with chroni liver injury significantly.