Preemptive analgesic effect of flurbiprofen axetii on patients with fracture of humerus after surgery

Objective: To observe the preemptive analgesic effect of flurbiprofen axetil on postoperative pain relief.Methods:Ninety-six humerus fracture patients(ASA I-Ⅱ) with surgery were randomly assigned into two groups.The patients in group I(n=48) received intravenous injection of flurbiprofen axetil 1 mg/kg 15 min before surgery,and those in groupⅡ(n=48) had intravenous injection of placebo 0.1 mL/kg.Postoperative analgesia efficacy was assessed by visual analog scales(VAS) at2 h,4 h,6 h,12 h,24 h after surgery.Fentanyl requirements and adverse effects were recorded at 24 h after surgery.The overall satisfaction to analgesic therapy was evaluated.Results: There was no significant difference in VAS between two groups at 2 h,4 h,6 h,12 h,24 h(P0.05).Requirements of fentanyl were significantly low in group I [(580.4±38.2) μg] than those in groupⅡ[(720.7±47.6) μg](P0.05).There was significant difference between the two groups in adverse effects(P 0.05).Conclusions: Flurbiprofen axetil can produce preemptive effect,reduce the requirements of fentanyl and the adverse effect,and enhance the quality of analgesia.