Clinical observation of Flurbiprofen Axetil Injection combined with intravenous Fentanyl in the postoperative analgesia

Objective:To observe the effect of Flurbiprofen Axetil Injection combined with intravenous Fentanyl in the postoperative analgesia.Methods:100 patients in ASA Ⅰ-Ⅱ level were randomly divided into two groups,the control group(group A) was given persistent intravenous Fentanyl,15 μg/h;the experimental group(group B) was given intravenous Flurbiprofen Axetil Injection of 1 mg/kg at 15 minutes before the operation and persistent intravenous Fentanyl 15 μg/h after the operation.The postoperative 1,3,6,12,18 and 24 h visual analogue scale(VAS) scores and analgesic satisfaction,the number of additional remedy analgesics and adverse reaction were observed and recorded.Results:The VAS analgesia score of group B at 1,3,6 and 12 h after operation were lower than group A(P0.01 or P0.05).At 18 h,the difference of the analgesia score between the two groups was not significant.The good rate of group A was 64%,which of group B was 96%,there was significant difference of analgesia good rate between the two groups(P0.05).During 1-12 h after operation,there were 18 patients in group A and 2 cases in group B needing to muscle note Pethidine to ease pain,with significant difference between the two groups(P0.05).Conclusion:The treatment of intravenous Flurbiprofen Axetil Injection of 1 mg/kg at 15 minutes before the operation can enhance the analgesic effect of the small dose of Fentanyl,reduce the dosage of Opioids at the same time and lower the adverse reaction rate.