Feasibility of preemptive analgesia of flurbiprofen axetil on post - OSAS patients pain relief

Objective To observe the preemptive analgesic effect of flurbiprofen axetil on post obstructive sleep apnea syndrome (OSAS) pain relief and studied its feasibilities. Methods Fifty patients (SAS Ⅰ-Ⅱ) were randomly assigned into two groups. The patients in group Ⅰ( n = 25) received intravenous injection of flurbiprofen axetil 100 mg 15 min before surgery, and those in group Ⅱ( n = 25) intravenous injection of saline 20 ml. Postoperative analgesia efficacy was assessed by visual analog scales (VAS) at 1,2,4,6,8,12 and 24 h after surgery. Tramadol and fentanyl requirements and adverse effects were recorded at 24 h after surgery. The overall satisfaction to analgesic therapy was evaluated. Results OSAS was lower in the group Iat 1,2,4,6 h ( P < 0. 05 ) than that in group Ⅱ. Requirement s of tramadol Ⅰ( 275±21 ) mg, requirement of fentanyl ( 275±21 ) μg were significantly less in group Ⅱ which Tramadl (298±23 ) mg, and Fentanyl (298±23) μg. The overall satisfaction to analgesic therapy was significantly different between two groups in grade Ⅱand Ⅳ( P < 0.05). Conclusion Flurbiprofen axetil can produce preemptive effect, save the requirements of tramadol and fentanyl, at the same time both reduce the adverse effect and increase quality of pain relief. Key words: Obstructive sleep apnea syndrome;  Preemptive analgesia ;  Flurbiprofen axetil ;  Tramadol; Fentanyl