Determination of Homocysteine in Patients with Type 2 Diabetic Nephropathy and its Clinical Significance

Objective To discuss the relationship between homocysteine and type 2 diabetic complicated with diabetic nephropathy.Methods 134 patients with type 2 diabetic were divided into normal proteinuria group(30 cases),microalbuminuria group(35 cases),clinical proteinuria group(38 cases) and chronic renal failure group(31 cases) according to 24 h urinary albumin excretion rate and serum creatinine.30 normal persons were chosen in normal control group.Then homocysteine was detected with cyclophorase method.Results The serum levels of homocysteine in type 2 diabetic groups were obviously higher than that in normal control group,and the levels were heightened with the increment of albuminuria and renal function damaged.Conclusions Homocysteine has relationship with diabetic nephropathy,and their levels are correlated with the degree of diabetic nephropathy.The levels of homocysteine can be used as the pathogenetic condition monitoring index of diabetic nephropathy.