Determination of Serum Homocysteine in Type 2 Diabetes Nephropathy and Its Clinical Significance

Objective To explore the relationship between homocysteine(HCY) and type 2 diabetes nephropathy and evaluate its clinical significance.Methods Totally 118 type 2 diabetic patients were classified into normal proteinuria group(n=37),incipient diabetic nephropathy group(n=44),and uremia group(n=37).The serum homocysteine levels of 118 patients and 55 healthy controls were detected and compared.Results Mean serum homocysteine levels of three experiment groups were significantly higher than that of control group(P0.01).There were statistically significant differences in serum homocysteine level between normal proteinuria group and incipient diabetic nephropathy group or uremia group(P0.01),as well as between incipient diabetie nephropathy group and uremia group(P0.01).With serum HCY level increased,nephropathy in type 2 diabetic patient would be severe.Conclusions Hyperhomocysteinemia may be an independent risk factor for diabetic nephropathy.The determination of the serum HCY level could be beneficial to clinical evaluation of the occurrence and development of T2DM.