CLINICAL SIGNIFICANCE OF HOMOCYSTEINE DETERMINATION IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY

Objective To evaluate the clinical significance of serum homocysteine determination in patients with type 2 diabetic nephropathy. Methods 146 patients with type 2 diabetic were divided into normal proteinuria group(30 cases),microalbuminuria group(42 cases),clinical proteinuria group(42 cases) and chronic renal failure group(32 cases)according to 24 h urinary albumin excretion rate and serum creatinine.30 normal persons were chosen as normal control group.Then homoeysteine was detected with cyclophorase method.Results The serum levels of homocysteine in type 2 diabetic groups were obviously higher than that in normal control group,and the levels were heightened with the increment of albuminuria and renal function damage.Conclusion Homocysteine has relationship with diabetic nephropathy.And their levels were correlated with the degree of diabetic nephropathy.The levels of homocysteine can be used as the pathogenetic condition monitoring index of diabetic nephropathy.