Distribution of infection sites and antimicrobial resistant analysis of Klebsiella pneumoniae in recent five years

Objective To investigate the distribution and antimicrobial resistance of Klebsiella pneumoniae in a hospital in recent five years, and provide reference for the rational use of antimicrobial agents in clinic. Methods The isolation rates and antimicrobial resistance of Klebsiella pneumoniae from different samples in a hospital between January 1999 and September 2003 were analyzed retrospectively. Results Infections caused by Klebsiella pneumoniae were frequently occurred in patients in intensive care units ( 35.60% ); and most strains ( 50.00% ) were isolated from sputum samples, imipenem was the most sensitive antimicrobial agents against Klebsiella pneumoniae infection, followed by amikacin and piperacillin/tazobactam, all strains of Klebsiella pneumoniae were resistant to ampicillin. The isolation rate of extended spectrum β lactamases (ESBLs) producing Klebsiella pneumoniae increased from 14.28% in 1999 to 46.00% in 2003, which was higher than that of non ESBLs producing Klebsiella pneumoniae. Conclusion Critical and immunocompromised patients are subject to infection caused by Klebsiella pneumoniae, antimicrobial resistant rates are increasing every year, the increased isolation of ESBLs producing Klebsiella pneumoniae in clinic should be paid attention.