Survey on Klebsiella pneumoniae distribution during 2008-2012 in a hospital of Hebei and its drug resistance

Objective To investigate drug resistance status of Klebsiella pneumoniae within five years in our hospital, and to provide references for control and therapy of Klebsiella pneumoniae infection. Methods Collected susceptibility data about Klebsiella pneumoniae from the inpatients in 2008-2012, and analyzed distribution of its departments, specimen type, drug resistance retrospectively. Results Klebsiella pneumoniae from sputum, mainly distributed in respiratory medicine and ICU ward, the five antimicrobial agents with highest resistance rate were ampicillin, piperacillin, cefazolin, aztreonam, cefuroxime, Klebsiella pneumoniae remained highly sensitive to cefoperazone / sulbactam, imipenem, meropenem, antimicrobial resistance of Klebsiella pneumoniae with ESBLs was significantly higher than that of non-ESBLs bacteria. Conclusion The drug resistance of Klebsiella pneumoniae has no significant growth trend, it should strengthen drug monitoring and rational use of antimicrobial drugs to reduce and slow down the generation of multiple-drug-resistant strains based on susceptibility results.