Interleukin-6 serum level and genotypes in patients with acute myocardial infarction

Objective To analyze polymorphism of the interleukin-6(IL-6)gene promoter-572C/G and - 634C/G in patients with acute myocardial infarction(AMI),and to study the rela tion between serum levels and genotype of interleukin-6.Methods The polymorphism of IL-6 was detected by polymerase chain reaction-r estriction fragment length polymorphism(PCR-RFLP)method in 128 AMI patients a nd 145 healthy persons,The serum level of IL-6 was determined by enzyme-linked immunosorbent assay(ELISA).Results AMI group showed significantly higher serum level of IL-6 than control group( P0.01).There was a significant difference in frequencies of allele and ge notype in IL-6 gene-572C/G polymorphism between AMI and control groups(P 0.01).IL-6 allele G carriers increased onset risk with 1.740 fold for AMI (OR=1.740,95%CI=1.135～2.668)compared with healthy persons.The dist ribution of IL-6 gene-634C/G polymorphism was not different between AMI group and control group(P0.05).Conclusion IL-6 gen e-572C/G polymorphism is associated with AMI.The IL-6 allele G carriers may be at increased risk of AMI due to enhanced the IL-6 expression.