Association of interleukin-6 gene promoter-572C/G and-634C/G polymorphisms in patients with cerebral infarction

Objective To study polymorphism of the interleukin-6(IL-6) gene promoter-572C/G and-634C/G in patients with cerebral infarction,and to study the relation between serum levels and genotype of interleukin-6.Methods The polymorphism of IL-6 was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method in 106 case cerebral infarction patients and 92 healthy persons,The serum level of IL-6 was determined by enzyme-linked immunosorbent assay(ELISA).Results cerebral infarction group showed significantly higher serum level of IL-6 than control group(P0.05).There was a significant difference in frequencies of allele and genotype in IL-6 gene-572C/ G polymorphism between cerebral infarction and control groups(P0.05).IL-6 allele G carriers increased onset risk with 1.634 fold for cerebral infarction(OR=1.634,95%CI=1.135～2.468) compared with healthy persons.The distribution of IL-6 gene-634C/G polymorphism was not different between cerebral infarction group and control group(P0.05).IL-6 gene-572C/G polymorphism is associated with cerebral infarction The IL-6 allele G carriers may be at increased risk of cerebral infarction due to enhanced the IL-6 expression.