The effects of high frequency oscillatory ventilation in premature infants with severe respiratory failure

Objective:To investigate the effects of high frequency oscillation ventilation(HFOV) in premature infants with severe respiratory failure.Methods:52 premature infants with severe respiratory failure were randomly assigned to two groups,26 premature infants were treated with conventional mechanical ventilation(CMV),another 26 premature infants were treated with high frequency oscillation ventilation(HFOV).Results:FiO2,PaCO2,OI decreased significantly and a/AO2 increased significantly in HFOV group after 6,12,24,48 hours ventilation.Be compared with before HFOV treating there was statistical significance(P0.05) or(P0.01).Be compared with CMV treating group there was statistical significance(P0.05);Duration of ventilation in HFOV group was less than CMV group,there was statistical significance(P0.05).Survival rates in th HFOV group was higher than CMV group,there was statistical significance(P0.05).Conclusion:HFOV can better improve arterial oxygenation and reduced the duration of ventilation in the premature infants with severe respiratory failure than CMV.As well as icreasing survival rates.HFOV is an effective method for premature infants with severe respiratory failure.