Therapeutic Effect of High Frequency Oscillatory Ventilation on Premature Infants with Respiratory Distress Syndrome

Objective To evaluate the effect of the high frequency oscillatory ventilation(HFOV) on the treatment of premature neonates with respiratory distress syndrome(RDS).Methods Seventy premature infants with RDS were randomly grouped as HFOV group(n=33) and conventional mandatory ventilation group(CMV group,n=37),based on their fetal age,weight,age,and their clinical condition from Jan.to Sep.in 2009.The blood gas analysis was detected and compared between the 2 groups.Results In HFOV group,the inhaled oxygen concentration,pa(CO2) decreased after treatment for 6 h,which were significantly lower than those at the beginning of the therapy(Pa0.01);While in CMV group,they decreased after 12 h treatment and the decreased extent was lower than those in HFOV group(Pa0.01).For the oxygen index(OI),it decreased after 12 h treatment in HFOV group(P0.01),which was significantly lower than that of CMV group(P0.01).For the pa(O2),it increased after 12 h treatment in HFOV group(P0.01),which was significantly higher than that of CMV group(P0.01).The incidence of air leak in the CMV group was higher than HFOV group(P0.05).Conclusion In the treatment of premature neonates with RDS,HFOV has a better pulmonary oxygenation and lower air leak than the CMV.