The Clinical Observation of High Frequency Oscillatory Ventilation in the Treatment of Neonatal Severe Lung Disease Complicated With Respiratory Failure

Objective To contrast the validity and security of treating neonates severe lung disease complicated with respiratory failure,between high frequency oscillatory ventilation(HFOV) and conventional mechanical ventilation(CMV). Methods 79 patients were treated by HFOV,80 patients were treated by conventional mechanical ventilation(CMV),there were differences in the oxygenate parameter,respiratory parameter,the cure rate,ventilator support days,length of stay,complications and so on between two groups,which were observed before and after treatment.Results In HFOV group,after 6h treatment ventilation oxygenation improved obviously,oxygen index(01) dropped to 8.82±3.98(P 0.05 ),PaO_2 rose to 73. 88±17.03 mmHg(P0.05) and PaCO_3 dropped to 38.51±5.03 mmHg(P0.05).After 24 h treatment FiO_2 and 01 reduced significantly,ventilator support days shortened,concurrent BPD and gas leak decreased,there were statistical differences between CMV group and HFOV group(P 0.05).Conclusion HFOV treatment in neonates severe lung disease complicated with respiratory failure could improve oxygenation faster,drop oxygen concentration and OI more faster in short time, shorten ventilator support days,reduce concurrent BPD and gas leak,and the clinical effect is satisfactory.