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Expression of FHIT Gene in Bladder Transitional cell Carcinomas

Xinyu Cao

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Abstract

Objective To investigate the expression characteristics of FHIT protein in bladder transitional cell carcinomas(TCC)and its relationship with clinicopathological parameters.Methods The expression of FHIT was studied by S-P immunohistochemisty in 10 cases of normal urinary bladder tissues and 62 cases of TCC.Results The positive rate of FHIT protein expression in normal urinary bladder tissues was 100%,the positive rate of FHIT protein expression in TCC was 46.77%(29/62),the expression of FHIT protein decreased with the increase of malignant degree,and had marked statistical significance(P0.05),the difference of positive rate between Tis～T1 and T2～T4 cases showed a trend of decrease,but there was no statistically significant difference(P0.05).Conclusion FHIT gene is related to occurrence and development of the bladder TCC.It could be regarded as a new useful diagnostic marker in the bladder TCC.

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What this paper is about

Objective To investigate the expression characteristics of FHIT protein in bladder transitional cell carcinomas(TCC)and its relationship with clinicopathological parameters.Methods The expression of FHIT was studied by S-P immunohistochemisty in 10 cases of normal urinary bladder tissues and 62 cases of TCC.Results The positive rate of FHIT protein expression in normal urinary bladder tissues was 100%,the positive rate of FHIT protein expression in TCC was 46.77%(29/62),the expression of FHIT protein decreased with the increase of malignant degree,and had marked statistical significance(P0.05),the difference of positive rate between Tis～T1 and T2～T4 cases showed a trend of decrease,but there was no statistically significant difference(P0.05).Conclusion FHIT gene is related to occurrence and development of the bladder TCC.It could be regarded as a new useful diagnostic marker in the bladder TCC.

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Available abstract

Objective To investigate the expression characteristics of FHIT protein in bladder transitional cell carcinomas(TCC)and its relationship with clinicopathological parameters.Methods The expression of FHIT was studied by S-P immunohistochemisty in 10 cases of normal urinary bladder tissues and 62 cases of TCC.Results The positive rate of FHIT protein expression in normal urinary bladder tissues was 100%,the positive rate of FHIT protein expression in TCC was 46.77%(29/62),the expression of FHIT protein decreased with the increase of malignant degree,and had marked statistical significance(P0.05),the difference of positive rate between Tis～T1 and T2～T4 cases showed a trend of decrease,but there was no statistically significant difference(P0.05).Conclusion FHIT gene is related to occurrence and development of the bladder TCC.It could be regarded as a new useful diagnostic marker in the bladder TCC.

Key concepts: FHIT, Transitional cell carcinoma, Urinary bladder, Significant difference, Urology, Medicine, Pathology, Immunohistochemistry

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