ADR Reports:Analysis of 120 Cases in Our Hospital

OBJECTIVE:To analyze the characteristics and regularity of the adverse drug reaction(ADR) occurred in our hospital so as to promote rational drug use.METHODS:By a retrospective study,a total of 120 ADR case reports collected from our hospital from Jan.to June in 2007 were subjected to a statistical analysis in respect of patients' age and sex,route of administration,drug categories inducing ADRs,the organs or system involved and the clinical manifestations etc.RESULTS:Of the total 120 ADR cases,68.3% were induced by intravenous administration,and 46.7% were induced by anti-infective drugs,followed by drugs used for nervous system and cardiovascular disease.Quinolones were the major anti-infective drugs,which caused ADR in 19 cases(33.9%),of all the quinolones used,levofloxacin took the lead.The ADRs manifested dominantly by skin rash and pruritus followed by lesions of digestive system and circulatory system.CONCLUSION:ADR monitoring should be strengthened and the related ADR reporting and analyzing system should be evolved to ensure clinical safe,effective and rational use of drugs.