Relation between chlamydia pneumoniae infection,von Willebrand factor and serum lipids with coronary heart disease

Objective To investigare the relation between chlamydia pneumoniae(Cpn)inrection and plasma levels of von willebrand factor(vWF)and serum lipids in coronary heart disease(CHD),in order to find out the probable mechanism of CHD.Methods According to the type of disease,120 cases of CHD patients were divided into acute myocardial infarction(AMI) group(44 cases),unstable angina pectoris(UAP)group(36 cases),stable angina(SAP)(40 cases).60 normal subjects were as control group.All people measured by microimmunofluorescence assayed Cpn antibodies,using enzyme-linked assayed vWF,measured by automatic biochemistry assayed lipids.Results The positive rate of Cpn specific antibody in AIM group and UAP group were higher than that in control group(P0.05).The levels of vWF total cholesterol(TC),triglyceride(TG),low density lilpoprotein cholesterol(LDL-C)in coronary patients were higher than that in control group(P0.05)and positively correlated to each other.The levels of vWF and TC,TG,LDL-C in seropositive were higher than seronegative individuals(P0.05)and they were positively correlated to the geometric mean titer(IgG).The levels of HDL-C were negatively with it.Conclusion Chronic infection with Cpn is significantly associated with CHD,it may contribute to the initiation and progression of atherosclerosis by inducing the proinflammatory cytokine vWF and cooperate with dyslipidemia,this promoted and increased the blood viscosity,the incidence rate of thrombus of artery is ascending.