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2011•The Journal of Pharmaceutical PracticeRequires access

Determination of Chlorogenic acid in Qingrexiaozhong oral liquid by HPLC

Sun Xue-xiong, Luo Chen-qu

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Abstract

Objective To develop a HPLC method for determining the content of Chlorogenic acid in QingRexiaozhong Oral Liquid.Methods The phenomenex Luna -C18(200 mm×4.60 mm,5 μm) was used;the mobile phase consisted of water -1% Aceticacid(20∶80),the flow rate of 1.00 ml/min,and the detecting wavelength was 326 nm.The column temperature was at 30 ℃.Results There was a good linearity for Chlorogenic Acid in the range of 0.163 1～1.087 2 μg,r=1.000(n=5),and the average recovery rate was 100.40%,RSD=1.20%(n=9).Conclusions The method was simple,accurate,reliable and reproducible,which could be available for the quality control of QingRexiaozhong Oral Liquid

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What this paper is about

Objective To develop a HPLC method for determining the content of Chlorogenic acid in QingRexiaozhong Oral Liquid.Methods The phenomenex Luna -C18(200 mm×4.60 mm,5 μm) was used;the mobile phase consisted of water -1% Aceticacid(20∶80),the flow rate of 1.00 ml/min,and the detecting wavelength was 326 nm.The column temperature was at 30 ℃.Results There was a good linearity for Chlorogenic Acid in the range of 0.163 1～1.087 2 μg,r=1.000(n=5),and the average recovery rate was 100.40%,RSD=1.20%(n=9).Conclusions The method was simple,accurate,reliable and reproducible,which could be available for the quality control of QingRexiaozhong Oral Liquid

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Available abstract

Objective To develop a HPLC method for determining the content of Chlorogenic acid in QingRexiaozhong Oral Liquid.Methods The phenomenex Luna -C18(200 mm×4.60 mm,5 μm) was used;the mobile phase consisted of water -1% Aceticacid(20∶80),the flow rate of 1.00 ml/min,and the detecting wavelength was 326 nm.The column temperature was at 30 ℃.Results There was a good linearity for Chlorogenic Acid in the range of 0.163 1～1.087 2 μg,r=1.000(n=5),and the average recovery rate was 100.40%,RSD=1.20%(n=9).Conclusions The method was simple,accurate,reliable and reproducible,which could be available for the quality control of QingRexiaozhong Oral Liquid

Key concepts: Chlorogenic acid, Chromatography, High-performance liquid chromatography, Chemistry, Recovery rate, Content determination

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