Comparison the clinical effects and safety of amisulpride and risperidone in the treatment of schizophrenia

Objective To compare the efficacy and safety of amisulpride and risperidone in the treatment of schizophrenia.Methods A total of 60 schizophrenics were randomized into trial group(n = 30) and control group(n = 30).Patients in the trial group dominated by negative symptoms taking amisulpride(400-1200 mg·d-1),and dominated by negative symptoms taking amisulpride tablets(50-300 mg·d-1).The patients in control group taking risperidone(2-6 mg);all for 6 weeks.The clinical effects were evaluated by positive and negative syndrome scale(PANSS) and CGI.And side effects were assessed by TESS at the time 2,4 and 8 weeks before and after treatment.Results The cure rate in trial group was 37.9% and efficacy rate was 82.8% after 6 weeks treatment.While 44.8% and 93.1% in control group.There were no statistical different between two groups(P 0.05).There was no significant difference in safety between the two groups.Conclusion The efficacy and safety rate of amisulpride and risperidone in the treatment of schizophrenia are the same.