Comparison study of amisulpride and risperidone in treatment of first-episode schizophrenia

Objective: To explore efficacy and safety of amisulpride in treatment of first-episode schizophrenia.Methods: 60 cases with first-episode schizophrenia were randomly divided into amisulpride group and risperidone group,and these cases were treated for 8 weeks.Positive and negative symptom scale(PANSS) and treatment emergent symptoms effect scale(TESS) were used to evaluate the efficacy and adverse effect,respectively.Results: After the treatment,the total effective rate of amisulpride group was 86.6% while that of risperidone group was 83.3%,and there was no significant difference between the two groups(P 0.05).The weight gain of amisulpride group was significantly less than that of risperidone group(P 0.05).Conclusions: Amisulpride and risperidone have a similar therapeutic effect,but the weight gain caused by amisulpride is significantly less.