Efficacy and safety of amisulpride compared with risperidone in schizophrenic patients

Objective To investigate the differences of efficacy and safety between amisulpride and risperidone in schizophrenic patients. Methods Totally 60 patients from Beijing Huilongguan Hospital were divided into amisulpride group(32 cases) and risperidone group(28 cases). Efficacy and safety were observed before and after treatment. Results ①Compared with baseline, the total score of PANSS had significant difference in both groups(P0.05) after the treatment. Compared with risperidone, the negative symptoms, cognitive function and depressive symptoms were improved significantly in amisulpride group(P0.05). ②There were no significant differences on the incidence of adverse reactions and interval of ECG at end point. Conclusion Amisulpride and risperidone are effective and safe in the treatment of schizophrenia.Compared with risperidone, amisulpride is relatively better on improving negative symptoms, depressive symptoms and cognitive function.